Poroelastic shape relaxation of hydrogel particles
نویسندگان
چکیده
We describe a straightforward way to determine the poroelastic diffusion coefficient of hydrogel particle by first indenting itviaswelling in granular packing, and then monitoring how its indented shape relaxes after it is removed.
منابع مشابه
Spherical indentation testing of poroelastic relaxations in thin hydrogel layers
In this work, we present the Poroelastic Relaxation Indentation (PRI) testing approach for quantifying the mechanical and transport properties of thin layers of poly(ethylene glycol) hydrogels with thicknesses on the order of 200 mm. Specifically, PRI characterizes poroelastic relaxation in hydrogels by indenting the material at fixed depth and measuring the contact area-dependent load relaxati...
متن کاملPoroelastic relaxation indentation of thin layers of gels
We develop a method of poroelastic relaxation indentation (PRI) to characterize thin layers of gels. The solution to the time-dependent boundary-value problem is obtained in a remarkably simple form, so that the force-relaxation curve obtained by indenting a gel readily determines all the poroelastic constants of the gel—the shear modulus, Poisson’s ratio, and the effective diffusivity. The met...
متن کاملSwelling behavior of nanoscale , shape - and size - specific , hydrogel particles fabricated using imprint lithography †
Recently a number of hydrogel-based microand nanoscale drug carriers have been reported including top down fabricated, highly monodisperse nanoparticles of specific sizes and shapes. One critical question on such approaches is whether in vivo swelling of the nanoparticles could considerably alter their geometry to a point where the potential benefit of controlling size or shape could not be rea...
متن کاملRelaxation effects of clustered particles.
Relations between spatial distribution of superparamagnetic iron oxide (SPIO) particles and the image contrast caused by SPIO were investigated. Actual clustering pattern of particles was measured in the liver and spleen of animals using intravital laser confocal microscopy. SPIO-doped phantoms with and without Sephadex beads were made to simulate these patterns, and relaxation parameters were ...
متن کاملPoroelastic swelling kinetics of thin hydrogel layers: comparison of theory and experiment
Thin poly(N-isopropylacrylamide) (PNIPAM) hydrogels were allowed to swell under two conditions: as freestanding layers and as substrate-attached layers. Through a combination of particle tracking and defocusing methods, the positions of beads embedded within the gels were monitored over time via fluorescence microscopy, providing a convenient method to track the kinetics of swelling for layers ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Soft Matter
سال: 2021
ISSN: ['1744-683X', '1744-6848']
DOI: https://doi.org/10.1039/d0sm02243h